Anti-Inflammatory Drug Design Using a Molecular Hybridization Approach

Anti-Inflammatory Drug Design Using a Molecular Hybridization Approach

The design of new drugs with better physiochemical properties, adequate absorption, distribution, metabolism, and excretion, effective pharmacologic potency and lacking toxicity remains is a challenge. Inflammation is the initial trigger of several different diseases, such as Alzheimer's disease, asthma, atherosclerosis, colitis, rheumatoid arthritis, depression, cancer; and disorders such as o...

P-44: Infertility and Non-Steroidal Anti- Inflammatory Drug Usage (An Experimental Design)

a:4:{s:10:"Background";s:391:"Unusual effect of celecoxib may be seen in some patients that have used this drug for a long time. Celecoxib is a form of non-steroidal anti-inflammatory drug (NSAID) that directly targets COX-2, an enzyme responsible for inflammation and pain which is the main feature of celecoxib. The goal of this survey is to assess the effect of celecoxib on male-reproductive s...

Oxygen: an anti-inflammatory drug.

• Vol 9 • December 2007 874 Impaired tissue oxygenation and cellular hypoxia are major components in the pathophysiology of a large variety of clinical conditions, including acute and chronic ischemia, wounds and tissue trauma, infections, physical and chemical injuries, as well as inflammatory joint and connective tissue diseases [1]. Tissue hypoxia triggers an inflammatory response. Mechanism...

Licofelone: A Novel Non-Steriodal Anti-Inflammatory Drug (NSAID) in Arthritis

Arthritis refers to different medical conditions associated with disorder of the primary structures that determine joint functions such as bones, cartilage and synovial membranes. Drug discovery and delivery to retard the degeneration of joint tissues are challenging. Current treatments of different arthritis involves administration of ideal non-steroidal anti-inflammatory drugs (NSAIDs) but ar...

In-silico drug design approach to discover novel anti-coagulants